https://www.harrisonlab.co.uk/general-1 daily 0.75 2023-03-16 https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588152637676-CLPGJ6F587OWZN0ZOUNR/microbiome4.png https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/664331c6-7a8d-4dbe-8c8d-061bf50fabee/plasmid+exchange.jpg https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588153782569-OI6ULVH018WMBWA33FJ0/plasmids+conjugating.png projects https://www.harrisonlab.co.uk/our-story daily 0.75 2021-07-17 https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588155318245-0AX4XEKXOE00A28KN498/Pan+genomes_barriers%3Adrivers1.png graphics https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1626559995382-6S6AX9T5DFS9VT7U8Y1X/figure.jpg graphics - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588154397020-8S3ZMUZL4X92CU6QPX8X/AMR+opinion+article_resub1.png graphics Looking at the issues of and solution for predicting whether resistance to novel antibiotics if likely to evolve. One major issue is that we make inferences from very simple assays done in the lab. Though that work can be useful there are a number of major reasons why these results are likely to be less than helpful in the ‘real world’..... Now out in Nature Ecology & Evolution https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588154473608-Y3X23NIPARHRQBTRVWPB/GA2_sRGB.jpg graphics https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588154328697-YJ6T7M9CA2CI75N3OJ4V/actP2.png graphics I created for a blog post for Jamie Hall's awesome paper on the impact of species interactions alter evolution to a niche. His results are shown in the right hand panel - He fond that when our favourite bacteria (white) evolved alone they break a costly cellular pump to increase their fitness. But in the presence of another (green) bacteria they don't. In his blog post Jamie compares this with the a couple of examples of where this has been seen in 'big' animals like the finches in the Galapagos (on the left) which evolved different beaks when a competitor invaded. But unlike the decades it takes for this to been observed, in bacteria these changes can be seen (and tested) over just a few weeks Read the summary here and the paper here https://www.harrisonlab.co.uk/home daily 1.0 2023-03-16 https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588341213215-4Y2BW1IAZSHFNH2JER7L/GA2_2.png Home - click for papers! https://www.harrisonlab.co.uk/team daily 0.75 2020-10-24 https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588932453939-YBKDOTZHIF0MI5LR9TMD/image.jpg people - Grace Wardell I am a PhD student currently studying soya-nodulating rhizobia and how introducing them to a non-native range, the UK, may impact our soil microbiome. I am investigating if the introduction induces changes in bacterial community composition and diversity, as well as looking for evidence of horizontal gene transfer of soya-nodulation genes into the native microbiome. I am particularly interested in mechanisms driving horizontal gene transfer in rhizobia, as the acquisition of symbiotic genes can provide huge benefits for the humble rhizobium! My project is cross -collaborative with the James Hutton Institute in Dundee and our commercial partner Plantworks UK. https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1588631051034-GXR5DG46J38WQY7HFBKF/DSC00273.jpg people - Ellie Harrison I’m currently a tenure track NERC fellow. Im interested in the forces that shape microbial communities. I’m often addressing this question at the sub-cellular level, focused on the menagerie of mobile genetic elements that exist within and between bacterial genomes. At present I am working on MGEs in Rhizobia - the bacteria that (sometimes) lives in the roots of legumes and provides them with lovely nitrogen. What a cracking bunch of lads. https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1603545617328-KXIO5PSP59VQMUDV2CYA/Dv37GcmR_400x400.jpg people - Mary Eliza Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1590068219364-A6A100VF9XB0ZXSAH4HN/Screenshot+2020-05-21+at+14.36.18.png people - Sam Ford Hello! I work as a research technician in the Harrison and Brockhurst labs trying to better understand the evolution of mobile genetic elements. In the Harrison group I work on Rhizobium phage genomics and with the Brockhurst group I work on Pseudomonas plasmid dynamics in the Rhizosphere. You will usually find me on a laptop trying to get code to run, or setting up soil-microcosms for evolution experiments in the lab. https://www.harrisonlab.co.uk/general-1-1 daily 0.75 2023-03-16 https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1603645349024-RNW4YLN5UDE7JKDY6UF2/Phage+AC+PhD.png opportunities - Don’t go out there! How do bacteria-phages interactions in the soil impact the rhizobia-legume symbiosis with Dr. Alex Best and Dr. Ville Friman (York) NERC funded via the ACCE doctoral training partnership We will apply experimental evolution and mathematical modelling to understand how antagonistic interactions outside of the plant host impact the relationship nitrogen fixing bacteria (rhizobia) have with their legume hosts. https://images.squarespace-cdn.com/content/v1/5ea88464acc8f650c10d17d0/1603645320359-FKG5GZLOKU47JT596I63/image-asset.png opportunities - The modular genome: how plasmids mediate major transitions in Rhizobium lifestyles With Prof Duncan Cameron & Prof Tim Daniell BBSRC funded via the White Rose doctoral training partnership We will use a multi-omics approach to understand the role of horizontal gene transfer and evolution in shaping the life history of Rhizobium - a highly adaptable genus that contains some of the worlds most important mutualists, as well as some notorious plant pathogens.